The overall analytical approach used in this study adhered to recommendations for undertaking generalised cost effectiveness analysis in the WHO CHOICE framework.7 Where prior regional analyses were available from the WHO CHOICE project,8 9 10 11 12 13 we used similar intervention definitions, modelling approaches, and costing methods. Here we summarise the methods and assumptions used in the https://en.wikipedia.org/wiki/Christian_Louboutin analyses.

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Conclusions The lower smoking related hazards reported previously in Japan may have been due to earlier birth cohorts starting to smoke when older and smoking fewer cigarettes per day. In Japan, as elsewhere, those who start smoking in early adult life and continue smoking lose on average about a decade of life. Much of the risk can, however, be avoided by giving up smoking before age 35, and preferably well before age 35.

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